fat-1 Antibody

1. Fat-1 transgenic mice express fat-1 from Caenorhabditis elegans. The kidneys of fat-1 mice showed better renal cell survival, renal function, and pathological damage than those of wt mice after Ischemia-Reperfusion Renal Injury. PMID: 28974016
2. Results suggest that endogenous omega-3 polyunsaturated fatty acids in APP/fat-1 mice could efficiently alleviate cognitive impairment and apathetic symptom comparing to their APP littermates. Neuronal survival and astrocytic activation were also observed ameliorated in APP mice after expression of fat-1 gene activated the NF-kappaB/Bcl-2 antiapoptotic pathway and inhibited the inflammatory response. PMID: 27474225
3. In the present study, endogenously increased levels of n-3 polyunsaturated fatty acids in the tumor tissues of omega3 fatty acid desaturase (fat1) transgenic mice was associated with a reduction in the growth rate of melanoma xenografts. PMID: 27573698
4. data suggest that the central n-3 PUFA increase observed in Fat-1 transgenic mice modulated the brain innate immune system activity . PMID: 25228141
5. Data (including data from studies in transgenic mice) suggest expression of fat1 prevents experimental rheumatoid arthritis; cultured synoviocytes respond differently to cytokine TNF (tumor necrosis factor-alpha) if recombinant fat1 is expressed. PMID: 25910895
6. Data indicate taht age-related impairments in glucose homeostasis are prevented in C. elegans fat-1 transgenic mice. PMID: 24211484
7. In mature adipocytes, fat-1 expression reduced lipid deposition, as measured by Oil Red O staining, and induced apoptosis. PMID: 23103373
8. Silencing of fat-1 transgene expression in sheep may result from hypermethylation of its driven cytomegalovirus (CMV) promoter. PMID: 22541322
9. The nematode mfat-1 effectively lowered the n-6/n-3 ratio in muscle and major organs of the transgenic pig. PMID: 22686479
10. The Fat-1 transgenic mice had lower BALF concentrations of the pro-inflammatory cytokines IL-1alpha, IL-2, IL-5, IL-9, IL-13, G-CSF, KC and RANTES PMID: 21616147
11. Transgenic mice expressing C. elegans fat-1 decreased hydrogen peroxide production and electron transport chain enzyme activities. PMID: 20856881
12. abundance of n-3 and a reduction in n-6 fatty acids in the organs and tissues of fat-1 transgenic mice, in the absence of dietary n-3 PMID: 14765186
13. the structural determinants of regioselectivity in FAT-1 and FAT-2 have been localized to two interdependent regions: a relatively hydrophobic region between the first two histidine boxes and the carboxyl-terminal region. PMID: 15226312
14. The fat-1 gene expression inhibited prostate cancer cell proliferation via reduction of GSK-3beta phosphorylation and subsequent down-regulation of both beta-catenin and cyclin D1. PMID: 18852124
15. Results from wild-type and fat-1 transgenic mice show that genes and proteins concerned with inflammation, apoptosis, neurotransmission, and neuronal growth and synapse formation are specifically modulated in fat-1 mice. PMID: 19138887

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KEGG: cel:CELE_Y67H2A.8

STRING: 6239.Y67H2A.8.1

UniGene: Cel.23442