fsn-1 Antibody

Code CSB-PA621106XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans fsn-1 Polyclonal antibody
Uniprot No.
Target Names
fsn-1
Alternative Names
fsn-1 antibody; C26E6.5F-box/SPRY domain-containing protein 1 antibody; F-box synaptic protein 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans fsn-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM and ALM neurons.
Gene References into Functions
  1. region of RPM-1 that is sufficient in binding to FSN-1 PMID: 25326385
  2. FSN-1 may negatively regulate insulin/IGF signalling, in part, through EGL-3-dependent insulin-like ligand processing. PMID: 23665919
  3. identification of FSN-1, a novel F-box protein that is required in presynaptic neurons for the restriction and/or maturation of synapses in Caenorhabditis elegans PMID: 15208641
  4. Identification of FSN-1 as a negative regulator of cep-1-dependent germ cell apoptosis. PMID: 18340346
Subcellular Location
Cell junction, synapse.
Protein Families
FBXO45/Fsn family
Tissue Specificity
Expressed in GABAergic neuromuscular junctions (NMJs).
Database Links

KEGG: cel:CELE_C26E6.5

STRING: 6239.C26E6.5

UniGene: Cel.22711

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