ago Antibody

Datasheet

Code	CSB-PA895217XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) ago Polyclonal antibody

Uniprot No.

Q9VZF4

Target Names

ago

Alternative Names

ago antibody; CG15010 antibody; F-box/WD repeat-containing protein 7 antibody; F-box and WD-40 domain-containing protein 7 antibody; Protein archipelago antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) ago protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. In the wing and eye, negatively regulates cell growth and proliferation by mediating the degradation of Myc and cyclin E, respectively. Required for endocycles, but not mitosis in follicle cell epithelium.

Gene References into Functions

these findings identify Ago as a required element of a circuit that suppresses the tracheogenic activity of larval muscle cells by antagonizing the Sima-mediated transcriptional response to hypoxia. PMID: 23459416
Ago loss induces hyperplasia of some organs but paradoxically reduces the size of the adult eye. PMID: 19733076
archipelago is an important inhibitor of Drosophila Myc in developing tissues, and can regulate Cyclin E levels and Notch activity. PMID: 15182669
novel function for the ago ubiquitin-ligase in tracheal morphogenesis via Trh and its target breathless, and suggest that ago has distinct functions in mitotic and post-mitotic cells that influence its role in development and disease PMID: 17976568

Subcellular Location

Nucleus.

Tissue Specificity

Expressed in follicle cell epithelium and imaginal disks, particularly in the morphogenetic furrow.

Database Links

KEGG: dme:Dmel_CG15010

STRING: 7227.FBpp0073101

UniGene: Dm.2559

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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ago Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background