FEN1 Antibody

Code CSB-PA686312XA01XAS
Product Type Polyclonal Antibody
Uniprot No. Q5I4H3
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) FEN1 protein
Raised in Rabbit
Species Reactivity Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (Flap structure-specific endonuclease 1) fen1
Immunogen Species Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
Gene Names fen1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Subcellular Location Nucleus, nucleolus, Nucleus, nucleoplasm, Mitochondrion
Protein Families XPG/RAD2 endonuclease family, FEN1 subfamily
Database Links

KEGG: xma:102228373

STRING: 8083.ENSXMAP00000006136

Pathway DNA repair pathway

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