fgf8a Antibody

1. Fgf8a signaling may have opposing actions on these two MG populations, they remain united in their response to Notch signaling inhibition, which stimulates both populations to enter an activated, but quiescent, state. PMID: 28445734
2. Loss of function of both fgf3 and fgf8a lead to a striking loss of the postchordal neurocranium that can be rescued by restoring Fgf3 and Fgf8a signaling centers in the brain and mesoderm. PMID: 27060628
3. A localized source of FGF8 placed adjacent to the nephric duct did not affect the duct migration path. PMID: 25516335
4. Fgf8 morphogen gradients in zebrafish embryos are established by two mechanisms. Firs Fgf8 is taken up into the cell by clathrin-mediated endocytosis. After endocytosis the routing of Fgf8 from the early endosome to the late endosome shuts down signaling. PMID: 24466061
5. Tbx1 controls the morphogenesis of pharyngeal pouch epithelia through mesodermal Wnt11r and Fgf8a. PMID: 25142463
6. FGF8 signaling is activated by glycosaminoglycans during zebrafish embryo development. PMID: 23614643
7. These studies provide evidence that a signaling pathway involving agrin, Fgfs and Shh may be a critical target of ethanol exposure during zebrafish embryogenesis. PMID: 23184466
8. heterozygote mutations in fgf8, shh or oep lead to a reduced number of ascending dopaminergic neurons in zebrafish and may confer increased susceptibility to the Parkinson disease PMID: 23123778
9. Fgf8a signaling governs cell fate in the zebrafish pineal complex PMID: 23250206
10. Activation of hs:fgf3 or hs:fgf8 during late blastula/early gastrula stages (5 hpf or earlier) resulted in complete dorsalization of the embryo PMID: 22327005
11. Retinoic acid signaling is required shortly after gastrulation in the forelimb field to temper Fgf8a signaling in the cardiac field, thus coordinating the development of the heart and forelimb. PMID: 21803036
12. Data show that positive feedback regulation of FGF signaling by Canopy1 (Cnpy1) controls DFC clustering. PMID: 21628557
13. Zebrafish piwil2 is a mediator of Fgf signals in gastrula period. PMID: 20814180
14. Data suggest that regulation of FGF8 morphogen signalling activity through endocytic sorting allows fast feedback-induced changes in gradient interpretation during the establishment of complex patterns. PMID: 21258372
15. Fgf has an essential role in establishing the period gradient that is required for the her1 spatial oscillation pattern at the emergence of the traveling wave. PMID: 20392739
16. Blocking FGF8 restores somite morphology in ChCh and Sip1a compromised embryos. PMID: 20034103
17. essential role for Setdb2-Fgf8 signaling in restricting dorsal organizer territory and regulating left-right asymmetry PMID: 20133783
18. FGF3 and FGF8, is required to establish correct segmental identity throughout the hindbrain and for subsequent neuronal development PMID: 12121619
19. Fgf8 and Fgf3 are required for zebrafish ear placode induction, maintenance and inner ear patterning PMID: 12385757
20. Data show that compromising Fgf3 and Fgf8 signaling or removing dlx3b, dlx4b and sox9a genes together blocks ear development. PMID: 12668634
21. During zebrafish fin development, Mkp3, a known MAPK/ERK regulator, is induced in the mesoderm by FGF8 signaling, through the PI3/Akt pathway. PMID: 12766772
22. During fin development,Mkp3, a known MAPK/ERK regulator, is induced in the mesoderm by FGF8 signaling, through the PI3/Akt pathway. PMID: 12776124
23. Our results do not support the previously suggested dominant roles for sonic hedgehog and Fgf8 in specification of the first catecholaminergic neurons, but instead indicate a novel role for Nodal signaling in this process PMID: 12843251
24. Data show that fibroblast growth factor (Fgf)8 and Fgf3 regulate different aspects of telencephalic development, and that Fgf3 alone is required for the expression of several telencephalic markers. PMID: 12900450
25. Results report the identification of a fibroblast growth factor (fgf) 8-related gene in zebrafish, fgf24, that is co-expressed with fgf8 in mesodermal precursors during gastrulation. PMID: 12925590
26. Fgf3 and Fgf8 as key regulators of cartilage formation in the vertebrate head. PMID: 14651935
27. Fgf (3 and 8) signals from rhombomere4, acting through the MapK pathway, then cooperate with Vhnf1 to activate val expression and subsequent rhombomere 5 and rhombomere 6 development PMID: 15342476
28. animals doubly reduced for Fgf8 and Fgf3 have severe reductions in hyoid cartilages and the more posterior branchial cartilages PMID: 15509770
29. fgf8 is required for proper asymmetric development of the brain, heart and gut and is necessary for proper symmetric development of the pharyngeal skeleton PMID: 15932752
30. Fgf8 drives terminal differentiation of a specific population of lateral muscle precursor cells within the early somite. PMID: 16120642
31. In the developing embryo, localised synthesis of retinoic acid by Raldh2 in the anterior psm and in somites activates fgf8 expression which in turn induces the expression of myogenic genes and fast muscle differentiation. PMID: 16316642
32. Results suggest that Atrophin2 plays a role in the feedback regulation of Fgf8 signaling. PMID: 16754885
33. impaired FGF signaling inhibits the repatterning of the anterior hindbrain and the reexpression of rhombic lip marker genes soon after cerebellar ablation PMID: 16822987
34. Results suggested that the fgf8 expression pattern is mediated by different regulatory regions in the upstream and downstream regions of the gene. PMID: 16961592
35. fgf8 can act as otic inducers PMID: 17239227
36. fgf8 has roles in zebrafish during skeletogenesis PMID: 17448458
37. Loss of FGF-expressing tissue in han mutants is responsible for the thyroid defects. PMID: 17611226
38. FGF signaling first regulates heart size and chamber proportionality during cardiac specification and later refines ventricular proportion by regulating cell number after the onset of differentiation. PMID: 18639539
39. This study presents a mechanism for breaking neuroanatomical symmetry through Fgf8-dependent regulation of bistable left- or right-sided migration of the parapineal. PMID: 19146810
40. Ier2 and Fibp1 mediate FGF signaling in ciliogenesis in Kupffer's Vesicle and in the establishment of laterality in the zebrafish embryo PMID: 19164561
41. Although fgf8 overexpression is known to be associated with breast and prostate cancer in mammals, this study provides the first evidence that fgf8 misregulation can lead to neural tumors. PMID: 19531571
42. The analysis of receptor-ligand interactions between D. rerio fgf8 and its receptors, fgfr1 and fgfr4, using combined spectroscopy methods are reported. PMID: 19648917
43. Fgf8 morphogen gradients are established and maintained by: fast, free diffusion of single molecules away from the source through extracellular space, and a sink function of the receiving cells, regulated by receptor-mediated endocytosis PMID: 19741606
44. fgf8a transcriptional regulation employs pan-vertebrate and teleost-specific enhancers dispersed over three genes in the zebrafish genome PMID: 19782672

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KEGG: dre:30538

STRING: 7955.ENSDARP00000018653

UniGene: Dr.478