htl Antibody

Datasheet

Code	CSB-PA445373XA01DLU
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) htl Polyclonal antibody

Uniprot No.

Q07407

Target Names

htl

Alternative Names

htl antibody; FR1 antibody; Tk1 antibody; CG7223Fibroblast growth factor receptor homolog 1 antibody; EC 2.7.10.1 antibody; DmHD-38 antibody; Protein heartless antibody; Tyrosine kinase 1 antibody; dTk1 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) htl protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

May be required for patterning of muscle precursor cells. May be essential for generation of mesodermal and endodermal layers, invaginations of various types of cells and CNS formation.

Gene References into Functions

Mactosylceramide, an early product in GSL biosynthesis, prevents inappropriate activation of insulin and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy. PMID: 28019653
Our data identify FGF signaling through Heartless as a key regulator of astrocyte morphological elaboration in vivo. PMID: 25033182
identify two transcriptional regulators that function downstream of Heartless signaling in lymph gland progenitors, the ETS protein, Pointed, and the Friend-of-GATA protein, U-shaped, which are required for this Heartless-induced differentiation response PMID: 23603494
identified a region within the N terminus of Dof protein that is required for FGF-dependent signal transduction and is necessary for efficient interaction of Dof with the FGF receptor Heartless PMID: 14993266
Htl is essential for the differentiation of dorsal mesodermal derivatives PMID: 15084280
the signal provided by the CAMs acts via the Heartless fibroblast growth factor receptor (FGFR) as outgrowth is reduced to basal levels in the presence of an FGFR inhibitor or if Heartless function is missing from the neurons. PMID: 15207853
Data suggest that the longitudinal visceral muscle founder cells (LVMFs) require the function of the Drosophila fibroblast growth factor receptor (FGFR) homolog, Heartless PMID: 15366011
Activation of Htl signalling produces a less prominent effect on FGF pathway on dorsal muscles than on lateral muscles.Extra founders of dorsal muscles are located in characteristic fashion that is different from that observed for excess lateral founders. PMID: 16207075
Mesodermal cell spreading is dependent on the FGF receptor Heartless. PMID: 17942486

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily

Tissue Specificity

In early embryos, expression is specific to mesodermal primordium and invaginated mesodermal cells. At later stages, expression is seen in putative muscle precursor cells and in the CNS.

Database Links

KEGG: dme:Dmel_CG7223

STRING: 7227.FBpp0082970

UniGene: Dm.7690

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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