btl Antibody

Code CSB-PA600971XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) btl Polyclonal antibody
Uniprot No.
Target Names
btl
Alternative Names
btl antibody; FR2 antibody; HD-311 antibody; Tk2 antibody; CG32134 antibody; Fibroblast growth factor receptor homolog 2 antibody; EC 2.7.10.1 antibody; Protein breathless antibody; Tyrosine kinase 2 antibody; dTk2 antibody; Tyrosine kinase receptor HD-311 antibody; dFGF-R1 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) btl protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
May be required for patterning of muscle precursor cells: generation of mesodermal and endodermal layers, invaginations of various types of cells, and CNS formation. Essential for the ability of the migrating tracheal and midline cells to recognize external guiding cues.
Gene References into Functions
  1. Time lapse imaging shows dynamic reorganization of branchless (bnl)-expressing cells and bnl-receptor breathless (btl) expressing trachea during embryonic development. PMID: 28502613
  2. Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency PMID: 23288848
  3. Study demonstrates that jing is required for btl expression in the branching trachea and dominantly interacts with known regulators of btl expression, including the ETS and POU transcription factors, pointed, and drifter/ventral veinless, respectively PMID: 21061018
  4. Branchless/Breathless signaling contains a positive feedback loop, which may guarantee a continuous supply of fresh receptors to membranes of growing tracheal branch cells PMID: 12175485
  5. In embryos, Fgfr1c was detected in osteoblasts of calvarial and mandibular bones. Fgfr3b and Fgfr3c were in chondrocytes in cranial base and mandibular condyle. Fgfr2b transcripts were detected in perichondria of mandibular condyle and cranial base. PMID: 12919696
  6. Data show that Downstream-of-FGFR is a substrate for fibroblast growth factor receptors (FGFRs) and recruits Corkscrew, leading to FGF-induced cell migration and activation of the Ras/MAPK pathway. PMID: 15082772

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily
Tissue Specificity
During embryogenesis, expression is seen in mesoderm, endodermal precursor cells, CNS midline cells and trachea and salivary duct ectodermal cells.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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