fkh Antibody

Code CSB-PA318580XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) fkh Polyclonal antibody
Uniprot No.
Target Names
fkh
Alternative Names
fkh antibody; CG10002Protein fork head antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) fkh protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Fkh promotes terminal as opposed to segmental development. In the absence of fkh, this developmental switch does not occur. The nuclear localization of the fkh protein suggest that fkh regulates the transcription of other, subordinate, genes.
Gene References into Functions
  1. FKH in the gut in mediating anti-aging effects of reduced insulin/insulin growth factor. PMID: 29045833
  2. Fkh maintains the expression of stem/progenitor cell markers and is required for stem cell proliferation during intestinal homeostasis and regeneration.It prevents intestinal stem/progenitor cells from precocious differentiation into the enterocyte lineage, likely in cooperation with bHLH/Daughterless. Its loss suppresses the intestinal tumorigenesis caused by Notch pathway inactivation. PMID: 29108672
  3. controls activation of Dpt and Mtk PMID: 24842780
  4. Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin PMID: 21217822
  5. FKH represses trachealess (trh), a duct-specific gene initially expressed throughout the salivary gland primordium. PMID: 12798300
  6. Fkh cooperates with the salivary gland-specific bHLH protein Sage to directly regulate expression of PH4alphaSG2, as well as sage itself, and to indirectly regulate expression of PH4alphaSG1. PMID: 16914497
  7. Fkh plays a pivotal role in the normal control of developmental cell death. PMID: 17339378
  8. Mapping of potential trithorax-associated regulatory elements within the extended (9 kb) promoter region of the fork head gene (fkh) in the Drosophila melanogaster salivary gland cells was performed. PMID: 17990516

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Subcellular Location
Nucleus.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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