Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans kpc-1 Polyclonal antibody

Uniprot No.

O17798

Target Names

kpc-1

Alternative Names

kpc-1 antibody; F11A6.1Furin-like protease kpc-1 antibody; EC 3.4.21.- antibody; CelfurPC protein antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans kpc-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Furin-like protease which cleaves proproteins at the RX(K/R)R consensus motif. During neuronal development, regulates the formation and extension of dendrite branches and cellular positioning of various type of neurons. Together with chin-1 and cdc-42, plays a role in the development of the neuropil and is required for the guidance of axons from neurons, including SubL pioneer neurons and AIY interneurons, into the nerve ring. Its role in axon guidance in glia and pioneer neurons may be through ensuring the fmi-1 protein is correctly localized to the nerve ring. Promotes the formation, extension and self-avoidance of dendritic branches of PVD and FLP mechanosensory neurons. In PVD neurons, regulates plasma membrane levels of branching receptor dma-1 by targeting it to late endosomes and thus promotes normal dendrite branching and dendrite self-avoidance. Also controls dendrite extension in AIY and D-type motoneurons, dendrite branching in AQR sensory neurons and VC4/5 motoneurons, the normal number of dendritic branches in AVL neurons and the positioning of HSN and ALM/PLM neurons. Dispensable for maintaining dendrite branching in adults. Also regulates dauer-specific dendritic branching of IL2 neurons and dauer-specific nictation behavior. Under adverse environmental conditions, may promote dauer formation by processing insulin-like proteins ins-1 and ins-18, two daf-2/InsR antagonists.

Gene References into Functions

We identify a Chimaerin (CHIN-1)- Furin (KPC-1) double-mutant that severely disrupts assembly. CHIN-1 and KPC-1 function noncanonically, in glia and pioneer neurons, for guidance-cue trafficking. PMID: 28846083
The authors show that KPC-1, a Caenorhabditis elegans furin homolog, regulates the level of the branching receptor DMA-1 on dendrites by targeting it to late endosomes. PMID: 26974341
The C. elegans furin homolog KPC-1 is required for dauer IL2 dendritic arborization and dauer-specific nictation behavior. KPC-1 is also necessary for dendritic arborization of PVD and FLP sensory neurons. PMID: 23932402

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, axon.

Protein Families

Peptidase S8 family, Furin subfamily

Tissue Specificity

Expressed in the nervous system including the ventral nerve cord, the nerve ring and the retrovesicular ganglion, and in epithelial cells. Expressed in IL2 neurons. Expressed in PVD mechanosensory neurons. Expressed in pharynx with strong expression in th

Database Links

KEGG: cel:CELE_F11A6.1

STRING: 6239.F11A6.1b

UniGene: Cel.22630

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kpc-1 Antibody

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