fng Antibody

Datasheet

Code	CSB-PA631542XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) fng Polyclonal antibody

Uniprot No.

Q24342

Target Names

fng

Alternative Names

fng antibody; CG10580Fringe glycosyltransferase antibody; EC 2.4.1.222 antibody; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) fng protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity; extends the O-linked fucose on the Notch EGF repeats. Boundary-specific cell-signaling molecule that is responsible for dorsal-ventral cell interactions during wing development.

Gene References into Functions

Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch. PMID: 27268051
FOXO-mediated regulation of fringe links the insulin and Notch signaling pathways in the germline stem cell niche. PMID: 23895933
molecular genetic analysis PMID: 12743367
suppresses effects of OFUT1 on Notch binding; decreases Serrate-Notch binding but increases Delta-Notch binding. PMID: 12909620
Fringe is required in the stretched cells and the anterior main body follicular cells to control stretched cell number and the timing of main body follicular cell displacement. PMID: 17420294

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Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Protein Families

Glycosyltransferase 31 family

Tissue Specificity

Expressed in dorsal cells.

Database Links

KEGG: dme:Dmel_CG10580

STRING: 7227.FBpp0077925

UniGene: Dm.4336

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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fng Antibody

Product Details

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Target Background