fos-1 Antibody

Code CSB-PA548118XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans fos-1 Polyclonal antibody
Uniprot No.
Target Names
fos-1
Alternative Names
fos-1 antibody; evl-5 antibody; F29G9.4Transcription factor fos-1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans fos-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGAPlays a role the development of the reproductive system, controlling events including anchor cell (AC) fusion and invasion. Regulates downstream transcriptional targets, including zmp-1, cdh-3, him-4 and mig10b, to promote the removal of the gonadal basement membrane during AC invasion. Regulates aff-1 expression to promote AC fusion. With jun-1 regulates egl-1 and lin-12 expression to allow uterine cell specification and development.; Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1.
Gene References into Functions
  1. This study describes the direct link from JNK signaling, Fos phosphorylation, and regulation of kreg gene transcription, which modulates the stress response in C. elegans. PMID: 23437011
  2. FOS-1, the Fos transcription factor ortholog that controls anchor-cell invasion during nematode development, is a specific activator of aff-1-mediated anchor-cell fusion.[Aff-1] PMID: 17488621
Subcellular Location
Nucleus.
Protein Families
BZIP family, Fos subfamily
Tissue Specificity
Expressed in anchor cells. Isoform a is expressed in somatic gonad cells that neighbor anchor cells. Isoform b is expressed in vulval cells, the uterine cells that neighbor anchor cells and the spermatheca.
Database Links

KEGG: cel:CELE_F29G9.4

STRING: 6239.F29G9.4b

UniGene: Cel.3822

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