kay Antibody

Code CSB-PA325100XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) kay Polyclonal antibody
Uniprot No.
Target Names
kay
Alternative Names
kay antibody; Fra antibody; CG15509 antibody; Transcription factor kayak antibody; isoforms A/B/F antibody; AP-1 antibody; Fos-related antigen antibody; Dfos antibody; dFra antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) kay protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra.
Gene References into Functions
  1. In wild-type ovarian cells, c-Fos is post-transcriptionally repressed by Piwi, which destabilized the c-Fos mRNA by promoting the processing of its 3' untranslated region (UTR) into Piwi-interacting RNAs (piRNAs). PMID: 27622269
  2. AP-1-dependent gene transcription is upregulated by increased neural activity during development. PMID: 23293292
  3. Clathrin and AP-1 colocalize at the trans-Golgi network; clathrin and AP-1 colocalize with secretory cargo at the TGN and on immature granules; loss of clathrin or AP-1 leads to a profound block in secretory granule formation. PMID: 21490149
  4. Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation. PMID: 17183370
  5. expression of Fos bZip elicits male-specific phenotypes. PMID: 18924113

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Subcellular Location
Nucleus.
Protein Families
BZIP family, Fos subfamily
Tissue Specificity
Early expression in the embryo is mesodermal and some of this expression is localized to a region surrounding the cephalic furrow. Later in embryonic development expression is ectodermal, corresponding to muscle attachment sites. Also observed in part of
Database Links

KEGG: dme:Dmel_CG33956

STRING: 7227.FBpp0288515

UniGene: Dm.6968

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