foxh1 Antibody

Code CSB-PA878004XA01DIL
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Product Details

Full Product Name
Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) foxh1 Polyclonal antibody
Uniprot No.
Target Names
foxh1
Alternative Names
foxh1 antibody; fast1 antibody; surForkhead box protein H1 antibody; Forkhead activin signal transducer 1 antibody; Fast-1 antibody; Schmalspur protein antibody
Raised in
Rabbit
Species Reactivity
Danio rerio (Zebrafish) (Brachydanio rerio)
Immunogen
Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) foxh1 protein
Immunogen Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry.
Gene References into Functions
  1. Axial mesoderm induction is differentially disrupted in FoxH1 mutants. FoxH1 mutants respond differently to Activin-like signaling. PMID: 21637786
  2. These results and the association of FoxH1 and Mixer/Bon with phosphorylated Smad2 support a role for these factors as components of the Nodal signaling pathway. PMID: 14522874
  3. flk1 is a direct target of FoxH1; FoxH1 is involved in vessel formation in zebrafish. PMID: 17306248
  4. to an essential role for maternal FoxH1 and downstream keratins during gastrulation that is epistatic to Nodal signaling PMID: 17719025
Subcellular Location
Nucleus.
Database Links

KEGG: dre:57930

STRING: 7955.ENSDARP00000072485

UniGene: Dr.7743

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