FPG1 Antibody

Code CSB-PA977806XA01DOA
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) FPG1 Polyclonal antibody
Uniprot No.
Target Names
FPG1
Alternative Names
FPG1 antibody; FPG2 antibody; At1g52500 antibody; F6D8.28Formamidopyrimidine-DNA glycosylase antibody; Fapy-DNA glycosylase antibody; EC 3.2.2.23 antibody; EC 4.2.99.18 antibody; DNA-(apurinic or apyrimidinic site) lyase FPG1 antibody; Formamidopyrimidine-DNA glycosylase 1 antibody; AtFPG-1 antibody; Formamidopyrimidine-DNA glycosylase 2 antibody; AtFPG-2 antibody; Protein MutM homolog 1 antibody; AtMMH-1 antibody; Protein MutM homolog 2 antibody; AtMMH-2 antibody
Raised in
Rabbit
Species Reactivity
Arabidopsis thaliana
Immunogen
Recombinant Arabidopsis thaliana FPG1 protein
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Can process efficiently 4,6-diamino-5-formamidopyrimidine (FapyA), 2,6-diamino-4- hydroxy-5-formamidopyrimidine (FapyG) and the further oxidation products of 8-oxoguanine (8-oxoG), such as guanidinohydantoin and spiroiminodihydantoin. Has marginal activity towards 8-oxoG. Has AP (apurinic/apyrimidinic) lyase activity. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Gene References into Functions
  1. The most striking difference between AthFpg and the bacterial Fpg proteins is the absence of the alphaF-beta9/10 loop, previously shown to be required for 8-oxoG recognition. PMID: 22789755
Subcellular Location
Nucleus.
Protein Families
FPG family
Tissue Specificity
Expressed in leaves (at protein levels).
Database Links

KEGG: ath:AT1G52500

STRING: 3702.AT1G52500.2

UniGene: At.11653

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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