FPS1 Antibody

1. Report shows that Slt2 is phosphorylated following arsenite treatment. Slt2 and its kinase activity are necessary for full acquisition of arsenite tolerance and this effect appears to be mediated through Fps1. Hence, it appears that two MAPKs, Hog1 and Slt2, collaborate in controlling arsenite influx and efflux through Fps1 suggesting a mechanism where this MAPK collaboration may function on Fps1. PMID: 27607883
2. Moreover, hyperosmotic conditions block TORC2-dependent Ypk1-mediated Fps1 phosphorylation, causing channel closure, glycerol accumulation, and enhanced survival under hyperosmotic stress. PMID: 26274562
3. results show the function of Stl1p and Fps1p transporters contributes to cell's ability to survive during transfer into state of anhydrobiosis; deletion of FPS1 decreases cell's tolerance of hyperosmotic stress; deletion of STL1 results in slight increase in cell size and increase in intracellular pH PMID: 25673653
4. Fps1 is key for downstream signaling in the Sho1-mediated branch of the high-osmolarity glycerol mitogen-activated protein kinase pathway pathway. PMID: 25644660
5. Activation of Hog1 in response to hyperosmotic shock induces the rapid eviction of Rgc2 from Fps1 and consequent channel closure PMID: 24298058
6. Data suggest a mechanism for regulation of glycerol flux in yeast, where the termini alone are not sufficient to restrict Fps1 transport. PMID: 22593571
7. Fps1 functions as a homotetramer to regulate glycerol transport in yeast. PMID: 22030956
8. Data show that Fps1p in concert with the arsenite transporter Acr3p mediates arsenite efflux. PMID: 20026328
9. Hog1 was also required for basal phosphorylation of ASK10, suggesting a mechanism by which Hog1 may regulate Fps1 indirectly PMID: 19956799
10. We showed that increased arsenite influx is dependent on the aquaglyceroporin Fps1p. Fps1p is phosphorylated on threonine 231 in vivo and this phosphorylation critically affects Fps1p activity. Moreover, Hog1p is shown to affect Fps1p phosphorylation. PMID: 16885417
11. These results suggest that, in addition to the efflux boron transporter BOR1, DUR3 and FPS1 play important roles in regulating the cellular boron concentration. PMID: 16923078
12. Improved production of ethanol by deleting FPS1. PMID: 17043906
13. HOG1 phosphorylation targets the FPS1 aqualglyceroporin for endocytosis, thereby rendering cells resistant to acetic acid. PMID: 17620418
14. Lack of Fps1p therefore exerts opposing effects on the activation of Hog1p and Slt2p in yeast exposed to acetic acid stress. PMID: 19608606
15. FPS1 expression contributes to decreased [(3)H]ethanol accumulation in yeast cells, suggesting that Fps1p may also play a role in maintaining the intracellular ethanol level during active fermentation. PMID: 19633105

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KEGG: sce:YLL043W

STRING: 4932.YLL043W