frh-1 Antibody

Code CSB-PA880020XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans frh-1 Polyclonal antibody
Uniprot No.
Target Names
frh-1
Alternative Names
frh-1 antibody; F59G1.7Frataxin antibody; mitochondrial antibody; Fxn antibody; EC 1.16.3.1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans frh-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization.
Gene References into Functions
  1. Demonstrate a causal connection between induction of autophagy and lifespan extension following reduced frataxin expression. PMID: 23247094
  2. Frataxin suppression by RNAi significantly extends lifespan in C. elegans. PMID: 15771615
  3. The genomic structure of frh-1, the development of an RNA interference model, and the interaction of frh-1 with mev-1 are reported. PMID: 16293572
  4. Study describes in detail the structure of all of the coding units within the CEOP2232 operon, coding for frataxin; it is composed of eight genes of a diverse nature, organized in a complex structure. PMID: 17174523
  5. Frataxin suppression by RNAi significantly reduces lifespan in C. elegans. PMID: 17215485

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Subcellular Location
Mitochondrion.
Protein Families
Frataxin family
Database Links

KEGG: cel:CELE_F59G1.7

STRING: 6239.F59G1.7.1

UniGene: Cel.20708

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