fh Antibody

1. we report that frataxin overexpression is sufficient to increase oxidative phosphorylation, modify mitochondrial morphology, alter iron homeostasis and trigger oxidative stress-dependent cell death. PMID: 28838288
2. The authors show that loss of frataxin homolog (fh) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2). PMID: 27343351
3. Frataxin overexpression in the nervous system reduces life span, impairs locomotor ability and causes brain degeneration. PMID: 21779322
4. Strong involvement of glial cells and lipid peroxidation in the generation of Friedreich's ataxia. PMID: 20460268
5. Defects in axonal transport of mitochondria appear late in development in distal nerve of larvae showing reduced frataxin expression, with retrograde movement preferentially affected. PMID: 20739558
6. H2O2 is an important pathogenic substrate underlying the phenotypes arising from frataxin deficiency in Drosophila PMID: 18184803
7. This suggests that Drosophila frataxin may function to protect the mitochondria from oxidative stresses and the ensuing cellular damage. PMID: 18258192
8. Dfh-assisted assembly of Fe-S clusters occurs with an observed kinetic rate constant ( k obs) of 0.096 min (-1) PMID: 18540637

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KEGG: dme:Dmel_CG8971

STRING: 7227.FBpp0071283

UniGene: Dm.2903