fln Antibody

Code CSB-PA327427XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) fln Polyclonal antibody
Uniprot No.
Target Names
fln
Alternative Names
fln antibody; FTN antibody; mp27 antibody; CG7445Flightin antibody; Muscle protein 27 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) fln protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Possibly involved in the regulation of flight muscles contraction, possibly by modulating actin-myosin interaction.
Gene References into Functions
  1. phosphorylation of D. melanogaster flightin is modulated during flight PMID: 26691840
  2. COOH terminus of flightin is necessary for normal myofilament lattice organization, thereby facilitating the cross-bridge binding required to achieve high power output for flight. PMID: 21593450
  3. used atomic force microscopy to study the morphological and mechanical properties of fully hydrated native thick filaments isolated from indirect flight muscle of normal and mutants lacking flightin PMID: 19917296
  4. Flightin is a major contributor to myofilament stiffness and a key determinant of the enhanced delayed force response to stretch in Drosophila flight muscles. PMID: 12954604
  5. Results illustrate the importance of flightin in flight muscle development and function. PMID: 15671343
  6. Myofilin is probably needed for filament assembly in all muscles, and flightin for stability of flight muscle thick filaments in adult flies PMID: 15769842

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Tissue Specificity
Found only in indirect flight muscles (IFM).
Database Links

KEGG: dme:Dmel_CG7445

STRING: 7227.FBpp0074679

UniGene: Dm.2517

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