ftsA Antibody

1. These results implicate the actin homolog FtsA in establishment of a Z-ring scaffold, while directly remodeling the membrane and provide mechanistic insight into localized cell wall remodeling, invagination and constriction at the onset of division. PMID: 29280220
2. results suggest that these bypass conditions enhance the weak interaction of FtsN with FtsA and its periplasmic partners so that the divisome proteins are brought to the Z-ring when the normal hierarchical pathway is disrupted. PMID: 29967164
3. FtsEX acts on FtsA to regulate both divisome assembly and activity. PMID: 27503875
4. FtsN acts on either side of the membrane to induce a conformational switch in both FtsA and the FtsBLQ subcomplex to de-repress septal peptidoglycan synthesis and membrane invagination. PMID: 25496160
5. overexpression of FtsN bypassed ZipA and a conserved motif in the cytoplasmic domain of FtsN was required for both the bypass and interaction with FtsA PMID: 25496259
6. These results suggest that allosteric effects, including changes in oligomeric state, may influence the ability of FtsA to bind and/or hydrolyse ATP. PMID: 25213228
7. These data support a model in which FtsA-FtsN interaction recruits FtsN to the divisome, where it can then stimulate the peptidoglycan remodelling activities required for SPOR-dependent localization. PMID: 24750258
8. FtsA self-interaction at the Z ring is antagonized by ZipA, allowing unpolymerized FtsA to recruit downstream proteins such as FtsN. PMID: 22111832
9. data indicate that domain 1C of FtsA participates in the interaction with other FtsA molecules and with the other proteins, but is not involved in the interaction with FtsZ and the localization of FtsA to the septal ring PMID: 15387815
10. subdomain 1c of FtsA is a completely independent functional domain with an important role in interacting with a septation protein subassembly. PMID: 15516588
11. FtsA, which is structurally related to eukaryotic actin, has a conserved C-terminal amphipathic helix that is essential for FtsA function; it is required to target FtsA to the membrane and subsequently to the Z ring PMID: 15752196
12. results suggest that FtsA* gain-of-function mutant interacts with FtsZ in a markedly different way compared with FtsA PMID: 17322202
13. FtsA is targeted to the membrane before it interacts with FtsZ and demonstrates that this interaction plays an essential role in E. coli cell division. PMID: 17501933
14. Data show dimerization or oligomerization of the actin-like FtsA protein enhances the integrity of the cytokinetic Z ring. PMID: 17986188
15. FtsA-W408E could localize to the Z ring and recruit the late cell division protein FtsI, but was defective in self-interaction and recruitment of FtsN, another late cell division protein. PMID: 18186792

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KEGG: ecj:JW0092

STRING: 316385.ECDH10B_0076