ftsK Antibody

1. FtsKgamma interacts with the C-terminal domain of XerD, above a cleft where XerC is thought to bind. We present a model for activation of recombination based on structural data. PMID: 27708355
2. We found that whatever the growth conditions, sister copies of the V. cholerae chr1 dif region remain together at mid-cell until the onset of constriction, which permits their processing by FtsK and the activation of dif-recombination. PMID: 28358835
3. FtsK translocase has a role in assembly, translocation, and activation of XerCD-dif recombination PMID: 26324908
4. An average of 7 FtsK hexamers per cell are present at midcell, with the N-terminal domain being able to hexamerize independently of the translocase. PMID: 24302254
5. Kinetic analyses showed that the presence of the FtsK gamma domain increases the rate of XerCD-dif synapse assembly and increases its stability. PMID: 24214995
6. Data indicate that the arrival of the FtsK translocase at an initial synaptic complex, forming a transient activated complex in which XerD exchanged a pair of strands to form an Holliday junctions (HJ) intermediate for catalysis by XerC. PMID: 24101525
7. FtsK segregates the terminus region of sister chromosomes whether they are monomeric or dimeric and does so in an accurate and ordered manner. PMID: 23781109
8. Multiple regions in FtsK protein are required for in cell division. PMID: 21091498
9. The properties in vivo and in vitro of FtsK and its relatives are discussed in relation to the biological functions of these remarkable enzymes. PMID: 20298190
10. FtsK transports DNA before membrane fusion, at a time when there is still an opening in the constricted septum. PMID: 20033058
11. FtsK translocation stops specifically at XerCD-dif, thereby preventing removal of XerCD from dif and allowing activation of chromosome unlinking by recombination. PMID: 19854947
12. Data describe the in vivo effects of deletions of FtsK(L) and/or of FtsK(C), of swaps of these domains with their Haemophilus influenzae counterparts and of a point mutation that inactivates the walker A motif of FtsK(C). PMID: 15522074
13. directly observed the movement of purified FtsK on single DNA molecules; results imply that FtsK is a bidirectional motor that changes direction in response to short, asymmetric directing DNA sequences PMID: 15681387
14. FtsK induces approximately 0.07 supercoils per DNA helical pitch traveled PMID: 15821742
15. translocation by FtsK occurs mostly on DNA belonging to a specifically organized domain of the chromosome, when physical links between either dimeric or still intercatenated chromosomes force this DNA to run across the septum at division PMID: 15916604
16. Results suggest that the N-terminal domain of FtsK is normally involved in stability of the division protein machine and shares functional overlap with FtsQ, FtsB, FtsA, ZipA and FtsN. PMID: 16194242
17. FtsK translocase is a powerful motor that is able to displace a triplex-forming oligo from a DNA substrate PMID: 16301526
18. A 62-amino-acid fragment of FtsK(C) interacts directly with the XerD C-terminus in order to stimulate the cleavage by XerD of BSN, a dif-DNA suicide substrate containing a nick in the 'bottom' strand. PMID: 16553881
19. Study provides evidence that 8-base-pair asymmetric sequences (KOPS) promote FtsK loading on DNA and that translocation is oriented at this step. PMID: 17041597
20. Study uses in vitro single-molecule and ensemble methods to unveil a mechanism of action in which the translocation and sequence-recognition activities are performed by different domains in FtsK. PMID: 17041598
21. controls recombination provoked by an extra Ter site in the chromosome terminus PMID: 17376083
22. Septum localization and concentration of FtsK co-ordinate its various roles in chromosome segregation and cell division. PMID: 18363794
23. FtsK interacts with the cell division partner proteins through different functional domians. PMID: 18759781
24. FtsK mediates a reciprocal control between processing of the replichore polarity junction and cell division. PMID: 19057667
25. Failure to recognize KOPS during FtsK translocation has only modest consequences for fitness of wild-type cells. PMID: 19170870
26. The structure and composition of DNA interferes with Xer recombination activation by FtsK. PMID: 19246541

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KEGG: ecj:JW0873

STRING: 316385.ECDH10B_0960