ftsL Antibody

1. the data suggest that FtsL forms an uninterrupted helix across the two regions and that the integrity of this helix is indispensable for the function of the complex. The FtsL helix is thus a candidate for acting as a potential mechanical connection to communicate conformational changes between periplasmic, membrane, and cytoplasmic regions. PMID: 29233891
2. results support a model in which FtsL, along with its partners FtsB and FtsQ, function as part of a sensing mechanism that promotes the onset of cell wall remodeling processes. PMID: 25496050
3. A structural model was developed for the periplasmic part of the FtsB/FtsL/FtsQ complex. PMID: 21672257
4. The authors demonstrate that the leucine zipper-like (LZ) motifs, located in the periplasmic domain of FtsL and FtsB, are required for an optimal interaction between these two essential proteins. PMID: 21784946
5. ftsL can confer a metal-ion sensitive phenotype and trans-membrane cysteine residues play a role in FtsL function in elevated metal-ion concentrations. PMID: 21708137
6. Study find that, as with FtsB, the C terminus of FtsL is required for the interaction of FtsQ with the FtsB/FtsL subcomplex while the cytoplasmic domain of FtsL is involved in recruitment of the downstream division proteins. PMID: 20363951
7. FtsL is associated in a hierarchical set of protein complexes and its assembly can occur independently of 'upstream' proteins. PMID: 16824093

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KEGG: ecj:JW0081

STRING: 316385.ECDH10B_0065