ftsN Antibody

Code CSB-PA326860XA01ENV
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Product Details

Full Product Name
Rabbit anti-Escherichia coli (strain K12) ftsN Polyclonal antibody
Uniprot No.
Target Names
ftsN
Alternative Names
ftsN antibody; msgA antibody; b3933 antibody; JW3904Cell division protein FtsN antibody
Raised in
Rabbit
Species Reactivity
Escherichia coli (strain K12)
Immunogen
Recombinant Escherichia coli (strain K12) ftsN protein
Immunogen Species
Escherichia coli (strain K12)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. Required for full FtsI activity. Required for recruitment of AmiC to the septal ring.
Gene References into Functions
  1. FtsN allosterically activates peptidoglycan synthesis by two pathways, one in the cytoplasm and involving FtsA, and the other in the periplasm and involving FtsQLB. PMID: 25571948
  2. Authors suggest a model wherein the overexpression of TolQ sequesters FtsN, depleting this essential protein from the divisome during Gram-negative cell division. PMID: 23818486
  3. The stability and function of the divisome is not guaranteed until FtsN is recruited. PMID: 20345660
  4. FtsN is the exception among the last proteins in that its targetting to midcell requires the presence of FtsA, FtsQ, and FtsI, and possibly many other proteins. PMID: 16824093
  5. Data show that FtsN interact with MtgA and help MtgA's role in peptidoglycan assembly during the cell cycle. PMID: 18165305
  6. The isolated SPOR domain ((S)FtsN) localized sharply to constriction sites, while SPOR-less FtsN derivatives localized poorly. PMID: 19684127

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Subcellular Location
Cell inner membrane; Single-pass type II membrane protein.
Protein Families
FtsN family
Database Links
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