ftz Antibody

Code CSB-PA365785XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) ftz Polyclonal antibody
Uniprot No.
Target Names
ftz
Alternative Names
ftz antibody; CG2047Segmentation protein fushi tarazu antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) ftz protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
May play a role in determining neuronal identity, may be directly involved in specifying identity of individual neurons. Required during embryogenesis for the process of body segmentation. Homeotic protein, required in alternating segment primordia, it specifies the correct number of segments.
Gene References into Functions
  1. FTZ(delta151-209) is a hyperactive FTZ molecule; the region encompassing amino acids 151-209 of FTZ is required in some manner for repression of FTZ activity PMID: 14654217
  2. Evolutionary acquisition of the LXXLL motif specialized Ftz for segmentation, while strengthening the Ftz/Ftz-F1 interaction led to degeneration of the YPWM motif and loss of homeotic activity. PMID: 15823536
  3. influences Ftz-F1 activity by interacting with its AF-2 domain in a manner that mimics a nuclear receptor coactivator PMID: 11520662
Subcellular Location
Nucleus.
Protein Families
Antp homeobox family
Tissue Specificity
Expressed early in development in a striped pattern at the blastoderm stage. Later expressed in a specific subset of neuronal precursor cells, neurons and glia in the developing CNS. Between 5 and 6 hours of development, found in the midline precursor-2 c
Database Links

KEGG: dme:Dmel_CG2047

STRING: 7227.FBpp0081139

UniGene: Dm.24032

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