Fur1 Antibody

Code CSB-PA328988XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Fur1 Polyclonal antibody
Uniprot No.
Target Names
Fur1
Alternative Names
Fur1; CG10772; Furin-like protease 1, isoform 1-CRR; Furin-1; Kex2-like endoprotease 1; dKLIP-1
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Fur1 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
Gene References into Functions
  1. Furin1 is a negative regulator of the Janus kinase/signal transducer and activator of transcription signaling pathway, which is implicated in stress responses in the fly. In summary, our data identify Furin1 as a novel regulator of humoral immunity and cellular stress responses in Drosophila PMID: 28705811
  2. alternative PE2 cleavage phenotypes observed in vertebrate and arthropod cells were due to differences in substrate specificity between the arthropod and vertebrate furin PMID: 20578951
Subcellular Location
Golgi apparatus membrane; Multi-pass membrane protein.
Protein Families
Peptidase S8 family, Furin subfamily
Tissue Specificity
In adults, isoform 1-CRR is expressed in CNS, fat body, and female reproductive tissues, and in embryos, in anal pads, hindgut, developing antennomaxillary complex, oenocytes, clipeolabrum, pharynx, trachea, CNS and developing posterior spiracles.
Database Links

UniGene: Dm.1740

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