fut-1 Antibody

Code CSB-PA174348XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans fut-1 Polyclonal antibody
Uniprot No.
Target Names
fut-1
Alternative Names
fut-1 antibody; CEFT-1 antibody; K08F8.3 antibody; Alpha-(1,3)-fucosyltransferase fut-1 antibody; EC 2.4.1.214 antibody; Fucosyltransferase fut-1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans fut-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Preferentially catalyzes the addition of fucose in alpha 1-3 linkage to the first GlcNAc residue (with or without alpha 1,6-linked fucose), next to the peptide chains in N-glycans. Unlike in mammals, does not require the prior action of N-acetylglucosaminyltransferase I to generate complex N-glycans.
Gene References into Functions
  1. different locations and capping of fucose meant that up to 13 isomeric structures, many highly galactosylated, were determined for mutants defective in two core fucosyltransferases each (fut-1;fut-6, fut-1;fut-8, and fut-6;fut-8) PMID: 26538210
  2. Caenorhabditis elegans FUT-1 contains a novel "first cluster motif", which is conserved in both core and Lewis-type alpha 1,3-fucosyltransferases of the GT10 family PMID: 21515584
Subcellular Location
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein Families
Glycosyltransferase 10 family
Tissue Specificity
Expressed in the pharyngeal-intestinal (PI) and anal valves. Expressed in ASG neurons and in one or two neurons in the retrovesicular ganglion and two neurons posterior to the PI valve and PHA and PHB neurons in the tail.
Database Links

KEGG: cel:CELE_K08F8.3

STRING: 6239.K08F8.3.1

UniGene: Cel.8786

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