Fasciculin-2 Antibody

Code CSB-PA314272ZA01DBG
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Product Details

Full Product Name
Rabbit anti-Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps) Fas-2 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
antibody; Fasciculin-2 antibody; Fas-2 antibody; Fas2 antibody; Acetylcholinesterase toxin F-VII antibody; Fasciculin-II antibody; FAS-II antibody; Toxin TA1 antibody
Raised in
Species Reactivity
Dendroaspis angusticeps
Recombinant Dendroaspis angusticeps Fasciculin-2 protein
Immunogen Species
Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Interferes with neuromuscular transmission by inhibiting the enzyme acetylcholinesterase (AChE) present at the neuromuscular junction. It selectively binds and inhibits with a 1:1 stoichiometry the mammalian and electric fish AChE at picomolar concentrations. It is highly specific for the peripheral site of AChE and blocks the entry of acetylcholine into the active site of the enzyme (through the Met-33 residue), thereby preventing its breakdown. It has been called fasciculin since after injection into mice it causes severe, generalized and long-lasting (5-7 hours) fasciculations.
Subcellular Location
Protein Families
Snake three-finger toxin family, Short-chain subfamily, Acn-esterase inhibitor sub-subfamily
Tissue Specificity
Expressed by the venom gland.
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