gag Antibody

1. Altogether, these data suggest that Gag targeting and membrane binding mediated by HTLV-1 matrix domain does not require phosphatidylinositol-(4,5)-bisphosphate and that distinct mechanisms regulate HIV-1 and HTLV-1 Gag membrane binding. PMID: 21289126
2. Nedd4.1 and Tsg101 act successively in the assembly process of HTLV-1 to ensure proper Gag trafficking through the endocytic pathway up to late endosomes where the late steps of retroviral release occur PMID: 15126635
3. beta-hairpin contributes to overall structure of mature capsid protein; differences in the backbone dynamics of the beta-hairpin contribute to mature capsid structure, possibly introducing flexibility into interface formation during proteolytic maturation PMID: 15569685
4. findings have shown that HTLV-1 Gag associates with CD82-enriched plasma membrane microdomains in Jurkat T cells PMID: 16325219
5. HTLV-1 gag proviral sequences were revealed in two cases of lymphoproliferative disorders such as angiolymphoid hyperplasia with eosinophilia (ALHE) and CD4+ cutaneous lymphoma, respectively. PMID: 16400878
6. data show that the HTLV-1 matrix protein may be phosphorylated by cellular ERK-2 kinase and indicate that phosphorylation of L-domain-containing proteins may be a common post-translational modification required for appropriate retroviruses budding PMID: 16635502

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KEGG: vg:1491934