gag Antibody

Datasheet

Code	CSB-PA322411XA01HLU
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) gag Polyclonal antibody

Uniprot No.

P18095

Target Names

gag

Alternative Names

gag antibody; Gag polyprotein antibody; Pr55Gag) [Cleaved into: Matrix protein p17 antibody; MA); Capsid protein p24 antibody; CA); Spacer peptide 1 antibody; SP1 antibody; p2); Nucleocapsid protein p7 antibody; NC); Spacer peptide 2 antibody; SP2 antibody; p1); p6-gag] antibody

Raised in

Rabbit

Species Reactivity

Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2)

Immunogen

Recombinant Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) gag protein

Immunogen Species

Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function

Mediates, with Gag-Pol polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi).; Targets the polyprotein to the plasma membrane via a multipartite membrane-binding signal, that includes its myristoylated N-terminus. Matrix protein is part of the pre-integration complex. Implicated in the release from host cell mediated by Vpu. Binds to RNA.; Forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. The core is disassembled soon after virion entry. Host restriction factors such as TRIM5-alpha or TRIMCyp bind retroviral capsids and cause premature capsid disassembly, leading to blocks in reverse transcription. Capsid restriction by TRIM5 is one of the factors which restricts HIV-1 to the human species. Host PIN1 apparently facilitates the virion uncoating. On the other hand, interactions with PDZD8 or CYPA stabilize the capsid.; Encapsulates and protects viral dimeric unspliced genomic RNA (gRNA). Binds these RNAs through its zinc fingers. Acts as a nucleic acid chaperone which is involved in rearangement of nucleic acid secondary structure during gRNA retrotranscription. Also facilitates template switch leading to recombination. As part of the polyprotein, participates in gRNA dimerization, packaging, tRNA incorporation and virion assembly.; Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.

Gene References into Functions

The differential requirement for adaptor protein complexes confirmed that HIV-1 and HIV-2 Gag have distinct cellular trafficking pathways, and that HIV-2 particles may be more susceptible to degradation prior to release. PMID: 27392064
These data on HIV-2 indicate that the role of the matrix domain in the nucleic acid chaperone activity of Gag differs not only between, but also within, retroviral genera. PMID: 26987314
These data show that infectious HIV-2 cannot bear the replacement of the reverse transcriptase Gln294 Pro, as it results in substantially reduced HIV-2 replication and fast reversions to the wild-type Gln294 virus. PMID: 25965791
This showed that V111I changed the flexibility of the 110-to-115 loop region, which may affect deoxynucleoside triphosphate (dNTP) binding and polymerase activity. PMID: 25355888
HIV-2 genome dimerization is required for the correct processing of Gag. PMID: 22419802
The N-terminal and C-terminal domains of the integrase were highly conserved. PMID: 21114823
analysis of the secondary active domain of HIV-2 NCp8 PMID: 17511966
The results show that all modifications of HIV-2 RT Gln294 lead to an increase of the RNase H activity of the enzyme relative to the wild-type. PMID: 18625228
C1-C4 region of HIV2 SU glycoprotein impairs utilization of the CCR5 and CXCR4 for viral entry. PMID: 19200444
These results suggest that the splicing of both the 5'UTR intron and the C-box element have key roles in regulation of HIV-2 gag translation in vitro and in vivo. PMID: 19559029

Hide All

Subcellular Location

[Gag polyprotein]: Host cell membrane; Lipid-anchor. Host endosome, host multivesicular body.; [Matrix protein p17]: Virion membrane; Lipid-anchor. Host nucleus. Host cytoplasm.; [Capsid protein p24]: Virion.; [Nucleocapsid protein p7]: Virion.

Protein Families

Primate lentivirus group gag polyprotein family

Promotions

Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

TNFRSF9: A Potent Immune-Stimulator in Cancer Cross-reactivity of Antibody: Beneficial or Harmful? Cellular Senescence and Its Markers DLL3: A New Molecular Target in Cancer With the High Potential in Cancer Immunotherapy, CD40 Is Triggering Attention CD31- A Complex Function Molecule CD73, What a Powerful Therapy Target in Tumor Immune The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application CD147, a New Target of SARS-CoV-2 Invasion DKK1: a Well-Characterized Wnt Inhibitor, a Multifunctional Regulator in Multiple Cancers! One World, One Hope——What Can We Do about AIDS? ACVRL1 (Alk1): a Member of the TGF-β Receptor Family, a Novel Target for Anti-Angiogenic Drug Research! What Factors Could Affect ELISA Results? Exploring Neurodegeneration: A Comprehensive Guide for Researchers Tools You Need For Fundamental Research CD48: An Emerging Human Immune Co-stimulatory Molecule, Friend or Foe? What A Paradoxical TNF Signaling Pathway-Based on Different Receptors CD146, A Powerful Tumor Marker CRTAM: Class I Restricted T cell-associated Molecule, an Intriguing New Member of the Ig-SF Family! An Overview of CD226 and Its Promising Role in Cancer Immunotherapy GLP-1R: An Energy Metabolism Regulator of GPCR Family, an Effective Drug Target for Type 2 Diabetes Therapy! Mucin-17/MUC17: An Unexpected Target for Tumor Immune Therapy, Notably Gastric Cancer! IL-17A: A Major Cytokine of the IL-17 Family, a Key Inflammation Target in Skin Diseases, or Inflammation-Associated Cancers! The Overview of Colony Stimulating Factors The Memory thief - Alzheimer's disease The Overview of Growth Factor The Overview of Interleukin Crosstalk Between Autophagy and Apoptosis Chemokine Receptor CCR6: the Specific Receptor for CCL20, a Potential Target for Drug Research in Inflammatory Diseases and Gastrointestinal Cancer! IL2RA (CD25): A Specific Marker of Tregs Functions as Both Immune Modulators and Targeted Agents in Various Diseases! GUCY2C: a Novel Target in Tumor Immunotherapy, Specially in Colorectal Cancer CAR T Therapy! Oncostatin M (OSM): A Member of IL-6 Cytokine Family, An Underestimated Player in Future Targeted Therapies? IL-6: an Important Participant in the Inflammatory Cascade, One of the Most Functional Cytokines in Various Diseases Research! Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

Join us with

Subscribe newsletter

Leave a message

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

gag Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background