GAP1 Antibody

1. The results presented here suggest some possible synergistic effects of phosphorylated Alp1, Gap1 and Can1 amino acid permeases on regulation of amino acid utilization and metabolism in Saccharomyces cerevisiae. PMID: 26865023
2. results support the concept that different substrates bind to partially overlapping binding sites in the same general substrate-binding pocket of Gap1, triggering divergent conformations, resulting in different conformation-induced downstream processes PMID: 24852066
3. Although the Bul proteins mediate Gap1 ubiquitylation of two possible lysines, Lys-9 and Lys-16, the Aly proteins promote ubiquitylation of the Lys-16 residue only. This stress-induced pathway of Gap1 down-regulation targets other permeases as well. PMID: 24942738
4. study show that Gap1 and Can1 permeases undergo ubiquitin-dependent endocytosis in response to their substrates and that this endocytosis is due to transport catalysis rather than intracellular substrate accumulation. PMID: 25266656
5. a possible mechanism involved in the regulation of Rsp5 activity for Gap1 down-regulation via the phosphorylation of a conserved Thr357 in the Nedd4 family is proposed PMID: 23517290
6. Internal amino acids promote Gap1 permease ubiquitylation via TORC1/Npr1/14-3-3-dependent control of the Bul arrestin-like adaptors. PMID: 22966204
7. Transport activity-dependent intracellular sorting of the yeast general amino acid permease PMID: 21471002
8. identified a self-propagating extrachromosomal circular DNA molecule that results from intrachromosomal recombination between long terminal repeats flanking GAP1 PMID: 20937885
9. In the present study, we found that Gap1p also catalyzed the uptake of putrescine and spermidine, but not spermine. PMID: 15707981
10. Mutations in LST4 and LST7 genes, previously identified for their role in Gap1p sorting, similarly block multivesicular endosome to plasma membrane trafficking of Gap1p. PMID: 16641373
11. Together, these studies provide evidence that the GSE complex has a key role in trafficking Gap1p out of the endosome and may serve as coat proteins in this process. PMID: 16732272
12. Together, our findings uncover a new mechanism for inhibition of permease activity in response to elevated amino acid levels and provide a physiological explanation for the stringent regulation of Gap1p activity in response to amino acids. PMID: 16885415
13. Coupled biogenesis of Gap1 and sphingolipid (SLs) would create an SL microenvironment essential to the normal conformation, function, and control of ubiquitination of the permease. PMID: 17553927
14. Gap1p activity is lowered in cells with an activated RAS2(val19) allele or elevated cAMP levels whereas cells with inactive ras2 allele lose ammonia repression of Gap1p-mediated transport PMID: 17919965
15. different ubiquitin signals act at the Golgi and plasma membrane to direct GAP1 trafficking PMID: 18434603
16. The mechanism of action of amino acid transport by Gap1, via a ligand-induced specific conformational change that may be part of but does not require the complete transport cycle, is reported. PMID: 19060912

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KEGG: sce:YKR039W

STRING: 4932.YKR039W