ASC1 Antibody

1. Data provide evidence that Asc1 seems to connect signal transduction not only with the translational machinery, but also with fundamental nuclear processes. PMID: 28982715
2. These indicate that ribosome-associated Asc1/RACK1 facilitates endonucleolytic cleavage of nonstop mRNA by stalled ribosomes and represses the levels of aberrant products even in the absence of Dom34. We propose that Asc1/RACK1 acts as a fail-safe in quality control for nonstop mRNA. PMID: 27312062
3. identify Asc1p (aka RACK1) and Rps3p, both stable 40S subunit components, as additional 18S nonfunctional 18S rRNA decay factors PMID: 28956756
4. It is the paper where ASC1 gene is identified and cloned and named. The effect of ASC1 deletion is also studied. PMID: 9504906
5. Translation fidelity depends upon Asc1-mediated quality control. PMID: 25792604
6. These results indicate the intertwined structure of a relatively small and stable protein core and the remaining regions of different levels of flexibility. PMID: 24591271
7. Genetic interactions between dys1-1 mutants and mutant PKC1 and ASC1, implicate a role for HYP2 (eIF5A homolog) and Asc1 in the maintenance of cell integrity at the translational level. PMID: 23573236
8. Evidence of the translational regulation of such transcription factors suggests that ribosomal Asc1p is involved in signal transduction pathways and controls the biosynthesis of the respective final transcriptional regulators. PMID: 23071099
9. The structure reveals an atypical mode of dimerization where monomers intertwine on blade 4, thus exposing a novel surface of the protein to potential interacting partners. PMID: 21704636
10. Asc1 functions as a G-protein beta subunit coupled to glucose responsiveness in yeast PMID: 17591772
11. RACK1 functions from the ribosome, implying a physical link between the eukaryotic ribosome and cell signaling pathways in vivo. PMID: 19114558

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KEGG: sce:YMR116C

STRING: 4932.YMR116C