exp-1 Antibody

Code CSB-PA184924XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans exp-1 Polyclonal antibody
Uniprot No.
Target Names
exp-1
Alternative Names
exp-1 antibody; H35N03.1 antibody; Gamma-aminobutyric acid receptor exp-1 antibody; Expulsion defective protein 3 antibody; GABA(A) receptor antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans exp-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells.
Gene References into Functions
  1. This experiment show that GABA mediates enteric muscle contraction in the nematode Caenorhabditis elegans via the EXP-1 receptor, a cation-selective ligand-gated ion channel. PMID: 14555952
  2. The intracellular region of EXP-1, an excitatory GABA receptor, specifically binds to calcineurin A; calcineurin functions as a negative regulator of excitatory GABA receptor in GABA signaling in C.elegans PMID: 16084527
Subcellular Location
Cell junction, synapse. Cell membrane; Multi-pass membrane protein.
Protein Families
Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
Tissue Specificity
Expressed in the intestinal and anal depressor muscles but not in the sphincter muscle. Also detected in the RID and SABD ring interneurons, the ADE sensory neuron and the PDA motor neuron.
Database Links

KEGG: cel:CELE_H35N03.1

STRING: 6239.H35N03.1

UniGene: Cel.14861

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