Rdl Antibody

Datasheet

Code	CSB-PA286897XA01DLU
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Rdl Polyclonal antibody

Uniprot No.

P25123

Target Names

Rdl

Alternative Names

Rdl antibody; CG10537 antibody; Gamma-aminobutyric acid receptor subunit beta antibody; GABA(A) receptor subunit beta antibody; Protein cyclodiene resistance antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Rdl protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Gamma-aminobutyric acid (GABA) receptor voltage channel subunit. GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. Together with glutamate receptor GluClalpha, plays an important role in the visual response by regulating the activity of ON/OFF-selective neurons. Plays a role in promoting sleep and sleep latency by regulating the activity of peptidergic PDF neurons. In large ventral lateral clock neurons, clustering is mediated by Nlg4 and protein levels undergo daily degradation in response to the circadian clock. In neurons in the mushroom bodies, has a role in odor memory acquisition where it inhibits appetitive and aversive olfactory learning, probably upstream of adenylyl cyclase rut and GTPase activating protein Nf1. In male-specific GABAergic neurons, plays a role in inhibiting male aggressive behavior during courtship.; Gamma-aminobutyric acid (GABA) receptor voltage channel subunit.

Gene References into Functions

overexpression of Rdl GABAARs in the motoneuron caused an increase in dendritic length and branch numbers in the distal GABAergic domain that came at the cost of a reduced arbor in the proximal cholinergic domain. PMID: 28132832
point mutations at the Rdl (Ala)301 site provide moderate resistance to phenylpyrazoles in D. melanogaster PMID: 25193377
Data indicate that duplication of the Rdl target site creates permanent heterozygosity, providing unique potential for adaptive mutations to accrue in one copy, without abolishing the endogenous role of an essential gene. PMID: 23959864
insulin-like peptides express the metabotropic GABA(B) receptor (GBR), but not the ionotropic GABA(A) receptor subunit RDL PMID: 21209905
model of the insect GABA receptor binding site and the location of agonists within it PMID: 20180551
Rdl containing GABA receptors play a direct role in mediating synaptic inhibition in Drosophila neural circuits formed in culture PMID: 12805302
The present study emphasizes new aspects of the pharmacological alterations induced by the Rdl mutation and shows that resistance to GABA receptor-directed insecticides may implicate a mutation distinct from Rdl. PMID: 15748149
RDL inhibits Drosophila olfactory associative learning. PMID: 18093529
Behavioral and physiological experiments indicated that Rdl(A302S) mutant flies are resistant to the effects of CBZ on sleep latency and that mutant RDL(A302S) channels are resistant to the effects of CBZ on desensitization, respectively. PMID: 18223647
RDL suppresses olfactory learning via involvement of the conditioned stimulus pathway. PMID: 19193904
Data show that RNA interference-mediated knockdown of the GABA(A) receptor gene, Resistant to dieldrin (Rdl), in PDF neurons reduces sleep, consistent with a role for GABA in inhibiting PDF neuron function. PMID: 19230663

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon.

Protein Families

Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily

Tissue Specificity

Expressed in different parts of the brain: the mushroom bodies (alpha, alpha', beta, beta', gamma lobes and peduncles), the neurons projecting to the columnar-type neuron LC9 optic glomerulus, in interneurons connecting the paired olfactory lobes, antenna

Database Links

KEGG: dme:Dmel_CG10537

STRING: 7227.FBpp0305970

UniGene: Dm.2698

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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