gck-3 Antibody

Code CSB-PA825066XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans gck-3 Polyclonal antibody
Uniprot No.
Target Names
gck-3
Alternative Names
gck-3 antibody; Y59A8B.23 antibody; Germinal center kinase 3 antibody; EC 2.7.11.1 antibody; STE20-like serine/threonine kinase antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans gck-3 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation-mediated inhibition of the chloride channel clh-3. In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1. Involved in several developmental processes including the tubular formation of the excretory canals, the formation of the intestine and the progression through larval stages. In addition, required for germ line development by controlling meiosis and chromosomal segregation during spermatogenesis. By controlling clh-3 activity, may regulate the development of the excretory canals and fertility.
Gene References into Functions
  1. Report role of multisite phosphorylation in regulating GCK-3 activity. PMID: 22357738
  2. We postulate that MEK-2/MPK-1 functions upstream from GCK-3 to regulate its activity during cell volume and meiotic cell cycle changes. PMID: 21160027
  3. The Caenorhabditis elegans gck-3 is essential for postembryonic developmental timing and regulates chromosome segregation. PMID: 20595048
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Tissue Specificity
Ubiquitously expressed with a higher expression in the excretory cell. Expressed in both male and female germ cells; up-regulated in maturing spermatocytes but absent in mature sperm.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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