odr-1 Antibody

Datasheet

Code	CSB-PA250714XA01CXY
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans odr-1 Polyclonal antibody

Uniprot No.

B1Q257

Target Names

odr-1

Alternative Names

odr-1 antibody; gcy-10 antibody; R01E6.1Receptor-type guanylate cyclase gcy-10 antibody; EC 4.6.1.2 antibody; Odorant response abnormal protein 1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans odr-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Guanylate cyclase involved in the production of the second messenger cGMP. Regulates chemotaxis responses toward volatile odorants in AWC sensory neurons and their avoidance in AWB sensory neurons. May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Involved in phototransduction in ASJ neurons downstream of G protein coupled-photoreceptor lite-1. Required to maintain the expression of putative olfactory receptor str-2 in AWC neurons in adults. In AWB and AWC sensory neurons, mediates the recognition of food oders which subsequently allows for the detection of preferred food sources.

Gene References into Functions

ASH sensory neurons are the primary nociceptors in C. elegans. We show here that the guanylyl cyclase ODR-1 functions non-cell-autonomously to downregulate ASH-mediated aversive behaviors and that ectopic cGMP generation in ASH is sufficient to dampen ASH sensitivity. PMID: 27459302
Study shows that the endo-siRNA pathway promotes odor adaptation in C. elegans AWC olfactory neurons. In adaptation, the nuclear Argonaute NRDE-3, which acts in AWC neurons, is loaded with siRNAs targeting odr-1, a gene whose downregulation is required for adaptation. PMID: 23993094

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell projection, cilium.

Protein Families

Adenylyl cyclase class-4/guanylyl cyclase family

Tissue Specificity

Expressed predominantly in AWC but also in AWB, ASI, ASJ and ASK sensory neurons and in I1 interneuron.

Database Links

KEGG: cel:CELE_R01E6.1

STRING: 6239.R01E6.1b

UniGene: Cel.811

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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