gcy-28 Antibody

Code CSB-PA448565XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans gcy-28 Polyclonal antibody
Uniprot No.
Target Names
gcy-28
Alternative Names
gcy-28 antibody; T01A4.1 antibody; Receptor-type guanylate cyclase gcy-28 antibody; EC 4.6.1.2 antibody; GCY-X1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans gcy-28 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Guanylate cyclase involved in the production of the second messenger cGMP. Regulates olfactory perception in AWC sensory neurons although may not be involved in the primary sensory transduction steps.; Isoforms c: Regulates sensory integration of conflicting sensory cues in AIA interneurons.; Regulates sensory integration of conflicting sensory cues in AIA interneurons.
Gene References into Functions
  1. GCY-28 and SCD-2 regulate sensory integration by modulating the activity of interneurons. Proper sensory integration is important for proper behavioral choices. PMID: 21414922
  2. Mutations in the receptor-type guanylate cyclase gcy-28 lead to an avoidance behavior in place of the attractive behavior normally directed by the olfactory AWC(ON) neuron. PMID: 18817734
Subcellular Location
[Isoform c]: Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Cell projection, axon. Perikaryon.; [Isoform d]: Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Cell projection, axon. Perikaryon.
Protein Families
Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity
Expressed in head neurons, ventral cord and tail neurons, body wall muscle, hypodermis, somatic gonad and intestine. Isoform d is expressed specifically in AIA interneurons.
Database Links

KEGG: cel:CELE_T01A4.1

STRING: 6239.T01A4.1c

UniGene: Cel.18007

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