gcy-35 Antibody

Code CSB-PA517297XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans gcy-35 Polyclonal antibody
Uniprot No.
Target Names
gcy-35
Alternative Names
gcy-35 antibody; T04D3.4Soluble guanylate cyclase gcy-35 antibody; EC 4.6.1.2 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans gcy-35 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyperoxia and for oxygen-induced aggregation and bordering, probably by mediating oxygen-sensing in URX, AQR and PQR sensory neurons.
Gene References into Functions
  1. joint loss of function of gcy-35 and npr-1 extends lifespan through reactive oxygen species signaling. PMID: 28054425
  2. The loss of GCY-35 or GCY-36 results in suppression of the small body size, developmental delay, and exploration defects exhibited by multiple bbs mutants PMID: 22022287
  3. Social feeding and related behaviors occur only when oxygen exceeds C. elegans' preferred level, and require gcy-35 activity; GCY-35 is regulated by molecular oxygen PMID: 15220933
Subcellular Location
Cytoplasm. Cell projection, dendrite.
Protein Families
Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity
Expressed in URX, AQR and PQR neurons. Also expressed in ALN, SDQ and BDU neurons, and variably in AVM, PLM and PLN neurons, pharyngeal and body wall muscles, and the excretory cell.
Database Links

KEGG: cel:CELE_T04D3.4

STRING: 6239.T04D3.4a

UniGene: Cel.30394

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