gcy-35 Antibody

Datasheet

Code	CSB-PA517297XA01CXY
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Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans gcy-35 Polyclonal antibody

Uniprot No.

O02298

Target Names

gcy-35

Alternative Names

gcy-35 antibody; T04D3.4Soluble guanylate cyclase gcy-35 antibody; EC 4.6.1.2 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans gcy-35 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyperoxia and for oxygen-induced aggregation and bordering, probably by mediating oxygen-sensing in URX, AQR and PQR sensory neurons.

Gene References into Functions

joint loss of function of gcy-35 and npr-1 extends lifespan through reactive oxygen species signaling. PMID: 28054425
The loss of GCY-35 or GCY-36 results in suppression of the small body size, developmental delay, and exploration defects exhibited by multiple bbs mutants PMID: 22022287
Social feeding and related behaviors occur only when oxygen exceeds C. elegans' preferred level, and require gcy-35 activity; GCY-35 is regulated by molecular oxygen PMID: 15220933

Subcellular Location

Cytoplasm. Cell projection, dendrite.

Protein Families

Adenylyl cyclase class-4/guanylyl cyclase family

Tissue Specificity

Expressed in URX, AQR and PQR neurons. Also expressed in ALN, SDQ and BDU neurons, and variably in AVM, PLM and PLN neurons, pharyngeal and body wall muscles, and the excretory cell.

Database Links

KEGG: cel:CELE_T04D3.4

STRING: 6239.T04D3.4a

UniGene: Cel.30394

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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gcy-35 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background