Recombinant Soluble guanylate cyclase gcy-35 (gcy-35), partial

Code CSB-YP517297CXY
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Source Yeast
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Code CSB-EP517297CXY
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Source E.coli
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Code CSB-EP517297CXY-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP517297CXY
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Source Baculovirus
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Code CSB-MP517297CXY
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
gcy-35; T04D3.4Soluble guanylate cyclase gcy-35; EC
Caenorhabditis elegans
Protein Length
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyperoxia and for oxygen-induced aggregation and bordering, probably by mediating oxygen-sensing in URX, AQR and PQR sensory neurons.
Gene References into Functions
  1. joint loss of function of gcy-35 and npr-1 extends lifespan through reactive oxygen species signaling. PMID: 28054425
  2. The loss of GCY-35 or GCY-36 results in suppression of the small body size, developmental delay, and exploration defects exhibited by multiple bbs mutants PMID: 22022287
  3. Social feeding and related behaviors occur only when oxygen exceeds C. elegans' preferred level, and require gcy-35 activity; GCY-35 is regulated by molecular oxygen PMID: 15220933
Subcellular Location
Cytoplasm. Cell projection, dendrite.
Protein Families
Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity
Expressed in URX, AQR and PQR neurons. Also expressed in ALN, SDQ and BDU neurons, and variably in AVM, PLM and PLN neurons, pharyngeal and body wall muscles, and the excretory cell.
Database Links

KEGG: cel:CELE_T04D3.4

STRING: 6239.T04D3.4a

UniGene: Cel.30394

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