gcy-8 Antibody

Code CSB-PA898253XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans gcy-8 Polyclonal antibody
Uniprot No.
Target Names
gcy-8
Alternative Names
gcy-8 antibody; C49H3.1Receptor-type guanylate cyclase gcy-8 antibody; EC 4.6.1.2 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans gcy-8 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Guanylate cyclase involved in the production of the second messenger cGMP. Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. Maintains the microvilli receptive ending morphology of the AFD thermosensory neurons by regulating cGMP levels downstream of kcc-3. cGMP levels antagonize the actin cytoskeleton regulator wsp-1.
Gene References into Functions
  1. three guanylyl cyclases (gcy-8, gcy-18, and gcy-23) function redundantly in the AFD neurons to mediate thermosensation by C. elegans PMID: 16415369
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell projection, cilium.
Protein Families
Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity
Expressed bilaterally in AFD sensory neurons.
Database Links

KEGG: cel:CELE_C49H3.1

STRING: 6239.C49H3.1

UniGene: Cel.56

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