Product Details

Full Product Name

Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) gdf6a Polyclonal antibody

Uniprot No.

P85857

Target Names

gdf6a

Alternative Names

gdf6a antibody; radar antibody; rdrGrowth/differentiation factor 6-A antibody; GDF-6-A antibody; Growth differentiation factor 6A antibody; Protein radar antibody

Raised in

Rabbit

Species Reactivity

Danio rerio (Zebrafish) (Brachydanio rerio)

Immunogen

Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) gdf6a protein

Immunogen Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryonic development. May be involved in maintaining the identity of cells of the dorsal-most neural tube and of at least a subset of neural crest cells.

Gene References into Functions

The role of Gdf6a signaling in superior ocular sulcus morphogenesis. PMID: 29522511
This work establishes a novel link between tbx2b and gdf6a in determining photoreceptor fates. PMID: 24681822
gdf6a is a dorsal initiation signal acting from the extraocular non-neural ectoderm during optic vesicle evagination. PMID: 22921921
Radar is regulated in the pharyngeal arches by a distant conserved element and has similar functions in skeletal development in fish and mammals. PMID: 20201106
Maternal induction of bone morphogenetic proteins by Radar is essential for zebrafish development as its removal results in larval-lethal dorsalized phenotypes. PMID: 12601179
Radar protein expression provides insights into dorsoventral patterning. PMID: 12682283
The spectrum of disorders generated by morpholino inhibition and the more severe defects (microphthalmia and anophthalmia) observed at higher doses illustrate the key role of GDF6 in ocular development. PMID: 17236135
These data establish the important role of growth differentiation factor 6 in ocular and vertebral development. PMID: 19129173
Radar is near the top of a signaling cascade that establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map PMID: 19164594
Gdf6a initiates dorsal retinal patterning independent of Bmp4, and regulates lens differentiation. PMID: 19545559

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Subcellular Location

Secreted.

Protein Families

TGF-beta family

Tissue Specificity

First expressed in late gastrula stage embryos (9.5 hours post fertilization (hpf)) in anterior neuroectoderm corresponding to the future dorsal part of the brain. Shortly after tailbud formation (11 hpf), expression expands to the entire neural region an

Database Links

KEGG: dre:566470

STRING: 7955.ENSDARP00000069999

UniGene: Dr.16432

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gdf6a Antibody

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