gsnl-1 Antibody

Code CSB-PA630334XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans gsnl-1 Polyclonal antibody
Uniprot No.
Target Names
gsnl-1
Alternative Names
gsnl-1 antibody; K06A4.3Gelsolin-like protein 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans gsnl-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development.
Gene References into Functions
  1. GSNL-1 acts downstream of the cell death pathway in synapse elimination. Cleavage of GSNL-1 by CED-3 induces synapse elimination. PMID: 26074078
  2. Calcium-sensitive activity and conformation of Caenorhabditis elegans gelsolin-like protein 1 are altered by mutations in the first gelsolin-like domain. PMID: 21840993
  3. GSNL-1 is a novel member of the gelsolin family of actin regulatory proteins with four gelsolin-like repeats PMID: 18640981
  4. Both conserved and different utilization of G domains between C. elegans GSNL-1 and mammalian gelsolin for actin regulatory functions. PMID: 20392036
Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
Villin/gelsolin family
Database Links

KEGG: cel:CELE_K06A4.3

STRING: 6239.K06A4.3

UniGene: Cel.3126

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