gld-2 Antibody

1. investigate whether the functions of the cytoplasmic poly(A) polymerase (cytoPAP) GLD-2 in C. elegans germ cells exclusively depend on its catalytic activity; findings highlight the enzymatic importance of noncanonical poly(A) polymerases and emphasize the pivotal role of poly(A) tail-centered cytoplasmic mRNA regulation in germ cell biology. PMID: 28490506
2. GLD-2 thus appears to have evolved specialized nucleotidyl-transferase properties that match the 3' end features of dormant cytoplasmic mRNAs PMID: 26124149
3. The analyses suggest that GLD-2 activity mediates mRNA stability of many translationally repressed mRNAs. PMID: 25217583
4. Data suggest that the FBF-2/GLD-2 protein directed polyadenylation of the endogenous mRNA, compensating for that mRNA's natural deadenylation. PMID: 21911377
5. Regulates Gld-1 messenger RNA in germ cells, enabling the transition from mitosis to meiosis. PMID: 17012378
6. FBF can affect polyadenylation either negatively by its CCF-1 interaction or positively by its GLD-2 interaction in control of GLD1 expression. PMID: 19221201
7. GLD-4 is predominantly expressed in germ cells, and its activity is essential for early meiotic progression of male and female gametes in the absence of GLD-2 PMID: 19339688

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KEGG: cel:CELE_ZC308.1

STRING: 6239.ZC308.1a

UniGene: Cel.9280