glh-1 Antibody

Code CSB-PA327356XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans glh-1 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
glh-1 antibody; T21G5.3ATP-dependent RNA helicase glh-1 antibody; EC antibody; Germline helicase 1 antibody
Raised in
Species Reactivity
Caenorhabditis elegans
Recombinant Caenorhabditis elegans glh-1 protein
Immunogen Species
Caenorhabditis elegans
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. Plays a role in positively regulating the localization of pgl-1 to P-granules. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development.
Gene References into Functions
  1. we show that removal of either of two critical P-granule components, PGL-1 or GLH-1, is sufficient to cause germ cells to express UNC-119::GFP and MYO-3 and to display RNA accumulation defects similar to those observed after depletion of P granules. Our data identify P granules as critical modulators of the germline transcriptome and guardians of germ cell fate. PMID: 28258184
  2. Data show that GLH-1 and its FG domain are not sufficient to form granules, but require factors like PGL-1 to nucleate the localized concentration of GLH proteins. PMID: 21402789
  3. the GLH-1/DCR-1 complex may function in the transport, deposition, or regulation of maternally-transcribed mRNAs and their associated miRNAs. PMID: 21146518
  4. KGB-1 and CSN-5 regulate GLH-1 levels, with GLH-1 targeted for proteosomal degradation by KGB-1 and stabilized by CSN-5. PMID: 17699606
Subcellular Location
Cytoplasm. Cytoplasmic granule. Cytoplasm, perinuclear region.
Protein Families
DEAD box helicase family, DDX4/VASA subfamily
Database Links

KEGG: cel:CELE_T21G5.3

STRING: 6239.T21G5.3

UniGene: Cel.19653

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