glr-1 Antibody

1. We also assessed ionotropic glutamate receptor GLR-1 cell-specifically within AIB and determined that GLR-1 fine-tunes AIB activity to modify locomotion following reversal events. Our research highlights that signal integration underlying the initiation and fine-tuning of backwards locomotion is AIB and NPR-9 dependent, and has demonstrated the suitability of C. elegans for analysis of multisensory integration PMID: 27223098
2. We propose a model in which synaptic activity regulates the nuclear localization of CMK-1 to mediate a negative feedback mechanism coupling GLR-1 activity with its own transcription. PMID: 27462879
3. Mutants lacking p38 MAPK components pmk-1 or sek-1 resemble mutants lacking the hypoxia response component and prolyl hydroxylase egl-9, with impaired subcellular localization of Mint orthologue LIN-10, internalization of glutamate receptor GLR-1, and depression of GLR-1-mediated behaviors. PMID: 26731517
4. KEL-8 is a substrate receptor for Cullin 3 ubiquitin ligases that is required for the proteolysis of GLR-1 receptors and suggest a novel postmitotic role in neurons for Kelch/CUL3 ubiquitin ligases. PMID: 16394099
5. glr-1 is required for long-term memory for habituation and memory for context conditioning. PMID: 23013276
6. Study indicates kinesin KLP-4 as a novel regulator of anterograde GLR-1 glutamate receptors trafficking and reveals a cellular control mechanism by which receptor cargo is targeted for degradation in tje absence of its motor. PMID: 22855524
7. An auxiliary protein SOL-2, a CUB-domain protein, associates with both the related auxiliary subunit SOL-1 and with the GLR-1 AMPA receptor. PMID: 22958824
8. Long-term memory in C. elegans is dependent on glr-1 and likely involves changes in the expression or localization of glutamate receptors PMID: 14573539
9. SOL-1 participates in the gating of non-NMDA (N-methyl-D-aspartate) iGluRs, thereby providing a previously unknown mechanism of regulation for this class of neurotransmitter receptor PMID: 14749834
10. GLR-1 is regulated in a homeostatic manner and this effect depends on clathrin-mediated endocytosis. PMID: 14981253
11. A critical period for the 3-day enhanced behavior and ionotropic glutamate receptor distribution was observed in first larval stage worms, whereas there was no critical period for the depressed effects observed in 5-day-old worms. PMID: 17054718
12. CDK-5 promotes the anterograde trafficking of GLR-1 and that phosphorylation of LIN-10 may play a role in this process. PMID: 17671168
13. GLR-1-mediated avoidance behaviors are completely disrupted in stg-1;stg-2 double mutants, and GLR-1-mediated currents are absent, despite apparently normal surface expression of GLR-1. PMID: 18817737
14. RPM-1 and PMK-3/p38 MAPK have roles in regulating the endosomal trafficking of AMPARs at central synapses PMID: 19172179

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KEGG: cel:CELE_C06E1.4

STRING: 6239.C06E1.4

UniGene: Cel.6005