glr-2 Antibody

Code CSB-PA608850XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans glr-2 Polyclonal antibody
Uniprot No.
Target Names
glr-2
Alternative Names
glr-2 antibody; B0280.12/K04G7.2Glutamate receptor 2 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans glr-2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. Required for response to mechanical and osmotic stimuli.
Gene References into Functions
  1. unfolded protein response signaling is a critical step in neural function that is needed for GLR-1, GLR-2, and GLR-5 assembly and secretion PMID: 15317844
  2. An arginine residue was introduced into the pore loop of glutamate receptor subunit, GLR-2. Synaptically activated GLR-2R-containing iGluR channels appear to trigger inappropriate, neurotoxic Ca2+ release from intracellular stores. PMID: 15371514
  3. Cytosolic tail sequences and subunit interactions of GLR-1 and GLR-2 are critical for synaptic localization of glutamate receptors PMID: 15840655
  4. previously-stimulated animals later habituate to subsequent mechanostimulation more rapidly compared to animals initially reared without mechanical stimulation; MAGI-1L, GLR-1, and GLR-2 are required for this change in habituation kinetics. PMID: 19242552
Subcellular Location
Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Protein Families
Glutamate-gated ion channel (TC 1.A.10.1) family
Tissue Specificity
Command interneurons of the locomotory control circuit (AIA, AIB, AVA, AVD, AVE, PVC, RIA, RIG and RIR) and motor neurons (AVG, M1, RMDD and RMDV).
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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