glc-2 Antibody

Code CSB-PA615033XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans glc-2 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
glc-2 antibody; F25F8.2Glutamate-gated chloride channel subunit beta antibody; Glu-Cl subunit beta antibody; Avermectin-sensitive glutamate-gated chloride channel subunit antibody
Raised in
Species Reactivity
Caenorhabditis elegans
Recombinant Caenorhabditis elegans glc-2 protein
Immunogen Species
Caenorhabditis elegans
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc-2 are activated by glutamate, but not by ivermectin (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid.
Subcellular Location
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein Families
Ligand-gated ion channel (TC 1.A.9) family, Glutamate-gated chloride channel (TC 1.A.9.4) subfamily
Database Links

KEGG: cel:CELE_F25F8.2

STRING: 6239.F25F8.2

UniGene: Cel.19753

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