goe Antibody

Code CSB-PA945010XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) goe Polyclonal antibody
Uniprot No.
Target Names
goe
Alternative Names
goe antibody; CG9634Protein gone early antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) goe protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays a role in the ovary in limiting the number of primordial germ cells (PGCs) that develop directly into gametes, allowing them instead to enter the developmental pathway that produces germline stem cells (GSCs) from PGCs and ensuring lifelong production of gametes from these GSCs. Negatively regulates epidermal growth factor receptor (Egfr) signaling. Probably down-regulates EGFR signaling on intermingled cells, a type of somatic stromal cell which contacts PGCs, and the resultant low level of signaling limits the proportion of PGCs which start gametogenesis, maintaining them in an undifferentiated proliferative state.
Gene References into Functions
  1. Data show that a germline factor, Gone early (Goe, CG9634) limits the fraction of primordial germ cells (PGCs) that initiate gametogenesis. PMID: 25420147
Subcellular Location
Cell membrane; Single-pass type II membrane protein.
Protein Families
Peptidase M13 family
Tissue Specificity
In late third larval instar ovaries, detected in germ cells but not in somatic intermingled cells and is expressed uniformly in the wing disk. In the embryo, expressed in the ventral midline, tracheal placodes, and cells forming the anterior-most row in e
Database Links

KEGG: dme:Dmel_CG9634

STRING: 7227.FBpp0074133

UniGene: Dm.7732

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