Gprk2 Antibody

Datasheet

Code	CSB-PA341365XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Gprk2 Polyclonal antibody

Uniprot No.

P32866

Target Names

Gprk2

Alternative Names

Gprk2 antibody; Gprk-2 antibody; CG17998 antibody; G protein-coupled receptor kinase 2 antibody; EC 2.7.11.16 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Gprk2 protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Specifically phosphorylates the activated forms of G protein-coupled receptors. Required during oogenesis and embryogenesis; component of a signaling pathway that functions during egg chamber maturation.

Gene References into Functions

pleckstrin homology domain of Gprk2 essential for enriching PI(4)P and facilitating Smo activation PMID: 26863604
based on findings, propose that Gprk2 attenuates and tunes Fog-Cta signaling to prevent apical constriction in lateral mesodermal cells and to support appropriate apical constriction in ventral mesodermal cells PMID: 24026125
Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling. PMID: 22096079
Oscillations in GPRK2 levels drive rhythms in gustatory physiology and behavior. PMID: 20153192
Data show that G protein-coupled receptor 2 (Gprk2) expression is required in the germline for proper formation of the anterior egg structures and for early embryogenesis. PMID: 12535651
Circadian-clock-dependent rhythms in GPRK2 abundance control the rhythmic accumulation of odorant receptors in olfactory sensory neuron dendrites. PMID: 18499458
Smoothened (Smo) is regulated by distinct Ptc-dependent and Gprk2-dependent trafficking mechanisms in vivo. PMID: 19850026

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Subcellular Location

Membrane. Note=Associated with nurse cell and oocyte plasma membranes during much of oogenesis.

Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily

Tissue Specificity

Expressed in all larval tissues and in adult ovaries. Larval CNS staining is localized to axons projecting to the optic lobes and the mushroom bodies, in the longitudinal connectives, and in cell bodies and nerves of the ring gland corpus allatum. Adult C

Database Links

KEGG: dme:Dmel_CG17998

STRING: 7227.FBpp0085149

UniGene: Dm.4430

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Gprk2 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background