DPAGT1 Antibody

1. present work improves our knowledge of DPAGT1-CDG and provides bases for developing tailored splicing and folding therapies PMID: 28662078
2. Data suggest that N-acetylglucosaminyl 1-phosphate transferase is a breast cancer therapeutic target. PMID: 25408354
3. Studies show that cells coordinate DPAGT1 expression and protein N-glycosylation with canonical Wnt signaling and E-cadherin adhesion via positive and negative feedback mechanisms. PMID: 23178939
4. prominent limb-girdle weakness and minimal craniobulbar symptoms who harbour a novel mutation in DPAGT1 PMID: 23591138
5. Patients with DPAGT1 CMS share similar clinical features with patients who have CMS caused by mutations in GFPT1, another recently identified CMS subtype. PMID: 23447650
6. Results indicate that the clinical spectrum of dolichyl-phosphate alpha-N-acetylglucosaminyltransferase (DPAGT1)-congenital disorders of glycosylation (CDG) is much broader than appreciated so far. PMID: 23249953
7. Data suggest that in oral squamous cell carcinoma (OSCC), dysregulation of canonical Wnt signaling and DPAGT1-dependent N-glycosylation induces CTHRC1, thereby driving OSCC cell migration and tumor spread. PMID: 23703614
8. suggest that the primary pathogenic mechanism of DPAGT1-associated CMS is reduced levels of AChRs at the endplate region. This finding demonstrates that impairment of the N-linked glycosylation pathway can lead to the development of CMS PMID: 23278575
9. Overexpression of DPAGT1 in human oral squamous cell carcinoma specimens is linked to aberrant activation of canonical Wnt signaling. PMID: 22341307
10. We identify DPAGT1 as a gene in which mutations cause a congenital myasthenic syndrome. PMID: 22742743
11. Mutations in DPAGT1 gene is associated with Congenital disorder of glycosylation type Ij. PMID: 22304930
12. up-regulation of DPAGT1 transcripts by Wnt3a led to altered N-glycosylation of E-cadherin. PMID: 20693288
13. REVIEW: Structure, expression, and regulation PMID: 19519349
14. Studies show for the first time that DPAGT1 is an upstream regulator of E-cadherin N-glycosylation status and adherens junction composition and suggest that dysregulation of DPAGT1 causes disturbances in intercellular adhesion in oral cancer. PMID: 19549906

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HGNC: 2995

OMIM: 191350

KEGG: hsa:1798

STRING: 9606.ENSP00000346142

UniGene: Hs.524081