grim Antibody

1. findings demonstrate that neuroblast apoptosis during embryogenesis requires the coordinated expression of the cell death genes grim and reaper, and possibly sickle PMID: 21558369
2. Programmed cell death of microchaete glial cells represents an exceptional opportunity to study the mitochondrial proapoptotic process induced by Grim. PMID: 20558283
3. When Grim is overexpressed in vivo, both the N-terminal & GH3 domains are equally necessary & cooperate for apoptosis induction. The N-terminal and GH3 Grim domains activate independent apoptotic pathways that synergize to induce programmed cell death. PMID: 12093734
4. Analysis of a Grim mutant that promoted XIAP degradation PMID: 14570909
5. role in countering DrICE inhibition by DIAP1 PMID: 15107838
6. Grim is located downstream of LKB1 and is invloved in LKB1 sependent apoptosis. PMID: 16273080
7. temperature shifts and dietary restriction, which slow the rate of aging in D. melanogaster, extend the window of neuronal susceptibility to GRIM over-expression in a way that scales to lifespan. PMID: 19428445

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KEGG: dme:Dmel_CG4345

STRING: 7227.FBpp0074896

UniGene: Dm.2372