grk Antibody

1. sites phosphorylated by CK2 overlap with active Orb and with Gurken protein expression. PMID: 27841697
2. The study suggests that both the localization and the translation of gurken mRNA in the vitellarium is independent from Vasa. PMID: 28207183
3. The translational regulation of gurken protein in nurse cells, where the transcript is synthesized, occurs by a different mechanism from that of oskar protein and bicoid protein mRNA in the oocyte. PMID: 26947065
4. reducing the function of eIF1A in spnB ovaries suppresses the ventralized eggshell phenotype by restoring Grk expression PMID: 25231760
5. A new pathway is identified that mediates cell-type and branch-specific synaptic repulsion, a novel role for EGFR signaling in synaptic target selection, and an unexpected role for Gurken as a muscle-secreted repulsive ligand. PMID: 22021126
6. The Syx1A dependent trafficking of Grk protein is required for efficient EGFR signaling during dorsal-ventral patterning. PMID: 23127433
7. Reduced TOR activity promotes grk translation independent of the canonical Vasa RNA helicase and cap-dependent mechanism. PMID: 22328499
8. grk, a host gene encoding a crucial axis determinant, is a key component of an mRNP complex that regulates Wolbachia proliferation in Drosophila oogenesis. PMID: 22193955
9. Data indicate that trapping at the anterodorsal corner requires at least one as-yet-unidentified gurken RLE. PMID: 21103393
10. pipe repression depends on the TGFalpha-like ligand Gurken, which activates the Drosophila EGF receptor in dorsal follicle cells. PMID: 12050143
11. mutation in the Drosophila Chk2 homolog (DmChk2/Mnk) suppresses the defects in the translation of gurken mRNA and also the defects in oocyte nuclear morphology PMID: 12361566
12. Bruno binds specifically to the gurken 3'UTR and that the dorso-ventral defects caused by Bruno over-expression are due to a reduction of Gurken levels in the oocyte, Bruno plays similar roles in translational regulation of gurken and oskar. PMID: 12591598
13. The two steps of gurken RNA transport occur on distinct arrays of microtubules. Such microtubule networks could provide a mechanism for one motor to transport different cargos to distinct subcellular destinations. PMID: 12636913
14. localization of gurken mRNA coupled to efficient sorting of Gurken out of the endoplasmic reticulum PMID: 15385627
15. Star interaction with arrest results in excess Gurken protein, supporting the model that gurken is a target of repression. PMID: 15579696
16. Production of gurken in the nurse cells is sufficient for axis determination in the Drosophila oocyte. PMID: 15829517
17. Data show that Cornichon (Cni), but not Cni-related, binds to the extracellular domain of Gurken (Grk), and propose that Cni acts as a cargo receptor recruiting Grk into COPII vesicles. PMID: 16396907
18. Disrupting Dynein function disperses gurken mRNA homogeneously throughout the cytoplasm, whereas the loss of Squid function converts the sponge bodies into active transport particles. PMID: 17925228
19. Results show that Gurken travels towards the lateral/posterior of the egg chamber in the absence of Cbl, suggesting that Cbl actively regulates Gurken distribution through promoting endocytosis and subsequent degradation. PMID: 18434418
20. a mitotic cell cycle checkpoint may impinge on grk expression, much as meiotic checkpoints can alter expression of this gene PMID: 18836312
21. Glorund is part of a complex containing the hnRNP protein Hrp48 and the splicing factor Half-pint and plays a role in gurken and oskar regulation. PMID: 19013444
22. Data suggest that that Squid interacts with gurken mRNA in the nurse cell nuclei and, together with other factors, maintains gurken in a translationally silent state during its transport to the dorsal anterior region of the oocyte. PMID: 19100729
23. Glycosphingolipids are necessary for full activation of the EGFR pathway during oogenesis in a time-dependent manner. PMID: 19144719
24. Bicaudal C and trailer hitch interact genetically. Mutants of these two genes have shared defects in localization of gurken and other anteriorly-localized mRNAs, as well as altered microtubule organization which may underlie the mRNA localization defects. PMID: 19217894
25. Germline clones of mutant Sec61beta show normal translocation of Gurken into the ER and transport to the Golgi complex, but further traffic to the plasma membrane is impeded. The defect in plasma membrane traffic is specific for Gurken. PMID: 19226464

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KEGG: dme:Dmel_CG17610

STRING: 7227.FBpp0079313

UniGene: Dm.355